Protein Details: Piezo-type mechanosensitive ion channel homolog
Protein ID
ICDB_Pro_0128
Protein Name
Piezo-type mechanosensitive ion channel homolog
Gene Name
At2g48060/At2g48040/At2g48050; T9J23.21/T9J23.19/T9J23.20
Organism
Arabidopsis thaliana (Mouse-ear cress)
Length
2462 amino acids
AlphaFoldDB
AF-F4IN58-F1-model_v4.pdb
Function
Pore-forming subunit of a mechanosensitive non-specific cation channel; that conducts both sodium and potassium ions.
Sequence
MASFLVGFLLPSLLLAAALINWSVISFLDLIAFLLVHYIAPEIGYRFQRRHWLLWPIFIFSFAVFLAQVVYLVIWAALGQDWDTPDTGWMRVIGFMILKSWRNPTVMYFLALQLLTSLVALADIYSSRFGFARWRDTWWSHFSGIFEHLGSHLRVASCLLLPAVQLAVGICNPSWVSLPFFIGSCAGLVDWSLTSNVSGLFRWWRVLYIYAGFNIVLLYLYQLPINFSDMIRWIASFIGLFRISLETEGPDICSGLFLVLFYIMLSYVRSDLEDMDFIMSTSENNLAERLLPPKYSFFIRESRAGVRHTNVLLRGAVFKTFSINFFTYGFPVSLFALSFWSFHFASLCAFGLLAYVGYIIYAFPSLFQLHRLNGLLLVFILLWAVSTYIFNVAFSFLNTKVGKFGLGMLVALGNLVNNSVFLYLSEESSRSSNERSYVEADEETKVLVVATIAWGLRKCSRAIMLALIFLIAMKPGFFHAVYVIFFLMYLLSHNINRKIRKSLILLCEVHFALLYILEIDLVSNSLKQEGSASREVLFQLGLLRSESSWDFLEIALLACFCAIHNHGFEVLFSFSAIVRHTPSPPIGFSILKAGLNKSVLLSVYSSPSSSYSQDNTTYERHIASFLSAIGQKFLSMYRSCGTYIAFITILISVYLVKPNYVSFGYIFLLLLWITGRQLFEETKRRLWFPLKAYAVLVFMFIYCLSSFVSLQLWLSGFIDLYFYLGYNSKAPLLDNVWESLAVLIVMQLYSYERRQSGHYIPGQSSLLHPGVFGFFERFLAWHGQKILFAALFYASLSPISVFGFVYLLGLVICTTFPKSSSIPSKSFLIYTGFLVSAEYLFQLWGMQAQMFPGQKYAELSFYLGLRVYEPGFWGIESGLRGKVLVVAACTLQYNVFRWLERTSGLTVIKGKYEEPCPLFVSAEDTTASVSSSNGENPSSTDHASISMKQGEATSNSWPFFSPRGNQGAGFLHPKTGGSESGSSRKFSFGHFWGSIKESHRWNRRRILALKKERFETQKNLLKIYLKFWIENMFNLYGLEINMIALLLASFALLNAISMVYIALLAACVLLRRRVIQKLWPVVVFLFASILAIEYVATWNSFLPSDQAPSETSVHCHDCWSIAALYFKFCRECWLGVRVDDPRTLISYFVVFMLACFKLRADHISSFSESSTYHQMKSQRKNSFVWRDLSFETKSMWTVLDYLRLYCYVHLLDVVLILILITGTLEYDILHLGYLAFALVFARMRLEILKKKNKIFRFLRVYNFVLIIFSLAYQSPFVGNFNDGKCETVDYIYEVIGFYKYDYGFRITARSALVEIIIFMLVSLQSYMFSSQEFDYVSRYLEAEQIGAIVREQEKKAARKTEQLQQIREAEEKKRQRNLQVEKMKSEMLNLRVQLHRMNSDSNFGVASPRTEGLRRRKSPYLIPDSGAASPEIDGVVHRKEEQPIDEDSQYPFEAHEFPVSTTPEALDSPEYSFGASPCEITEVQQDLDVMSMERERKQKSEGKENPLISAVQLIGDGVSQVQFIGNQAVNNLVNFLNISPENSDTNEQSSVDDEVYDEMESQKRKHTPFERSTSLQSDRSSDGTSFQIGRIFRHIWSRMQSNNDIVCYCCFIIAFLWNFSLLSMVYLAALFLYALCVHTGPTHIFWVIMLMYTEIYILLQYLYQIIIQHCGLSIDAPLLHELGFPTQRIKSSFVVSSLPLFLIYIFTLIQSSITVKDGDWVPSADFTSRRNARGSQKDLTRIRLSQRILDVFKKLRDSAKLVIRSIYRYWISLTRGAESPPYFVQVTMDVHMWPEDGIQPERVECRMNQLLRLVHNERCEKGNPDLCPYSSRVHVQSIERSTETPNEALVVLEVEYASPTNGCSSAEWYKSLTPASDVAKEIRKAQHSGLGEGTGFPYPILSVIGGGKRDTDLYAYIFGADLIVFFLVAIFYQSVIKNKSEFIDVYQLEDQFPFDFVIILMVIFFLIVVDRVIYLCSFATGKVVYYLFSLILFTYAVTEYAWSIYPTQQHAAGLALRIIFLAKAMSLALQAIQIRYGLPHKSTLYRQFLTSEVSRINYYGYRLYRALPFLYELRCVLDWSCTATSLTMYDWLKLEDVNASLYLVKCDTVLNRATHKHGEKQTKMTKCCNGICLFFILLCVIWAPMLMYSSGNPTNIANPIKDASVQIDLKTVGGKLTLYQTTLCERISGDNIDLGLDLGSQSFLPTYNKNDIQLICCQADASVLWLVPDTVVTRFIQSLDWDTDMDITFTWVLNRDRPKGKETVKYERSVDPLDLPKRSDIQMVLNGSMDGFRVHNLYPKFFRVTGSGDVRSFEDQTDEVSADILINHANFKWWWSFHNLKASENISACEGMDGPVAIIMSEETPPQGFLGDTLSKFSIWGLYITFVLAVGRFIRLQCSDLRMRIPYENLPSCDRLIAICEDLYAARAEGELGVEEVLYWTLVKIYRSPHMLLEYTKLDYDA
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1038/45471; 10.1111/tpj.13415; 10.1104/pp.010207
RefSeq
NP_182327.6